Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney
Identifieur interne : 000354 ( Main/Exploration ); précédent : 000353; suivant : 000355Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney
Auteurs : Anthony Josephine ; Ganapathy Amudha ; Coothan Kandaswamy Veena ; Sreenivasan P. Preetha [Inde] ; Arjunan Rajeswari ; Palaninathan VaralakshmiSource :
- Molecular Nutrition & Food Research [ 1613-4125 ] ; 2007-11.
English descriptors
- KwdEn :
Abstract
Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.
Url:
DOI: 10.1002/mnfr.200700127
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000399
- to stream Istex, to step Curation: 000243
- to stream Istex, to step Checkpoint: 000136
- to stream Main, to step Merge: 000355
- to stream Main, to step Curation: 000354
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title><author><name sortKey="Josephine, Anthony" sort="Josephine, Anthony" uniqKey="Josephine A" first="Anthony" last="Josephine">Anthony Josephine</name></author><author><name sortKey="Amudha, Ganapathy" sort="Amudha, Ganapathy" uniqKey="Amudha G" first="Ganapathy" last="Amudha">Ganapathy Amudha</name></author><author><name sortKey="Veena, Coothan Kandaswamy" sort="Veena, Coothan Kandaswamy" uniqKey="Veena C" first="Coothan Kandaswamy" last="Veena">Coothan Kandaswamy Veena</name></author><author><name sortKey="Preetha, Sreenivasan P" sort="Preetha, Sreenivasan P" uniqKey="Preetha S" first="Sreenivasan P." last="Preetha">Sreenivasan P. Preetha</name></author><author><name sortKey="Rajeswari, Arjunan" sort="Rajeswari, Arjunan" uniqKey="Rajeswari A" first="Arjunan" last="Rajeswari">Arjunan Rajeswari</name></author><author><name sortKey="Varalakshmi, Palaninathan" sort="Varalakshmi, Palaninathan" uniqKey="Varalakshmi P" first="Palaninathan" last="Varalakshmi">Palaninathan Varalakshmi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:878595168592A567E3CAD88E8FC7A3C93BE2C88F</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mnfr.200700127</idno><idno type="url">https://api.istex.fr/document/878595168592A567E3CAD88E8FC7A3C93BE2C88F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000399</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000399</idno><idno type="wicri:Area/Istex/Curation">000243</idno><idno type="wicri:Area/Istex/Checkpoint">000136</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000136</idno><idno type="wicri:doubleKey">1613-4125:2007:Josephine A:beneficial:effects:of</idno><idno type="wicri:Area/Main/Merge">000355</idno><idno type="wicri:Area/Main/Curation">000354</idno><idno type="wicri:Area/Main/Exploration">000354</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney</title><author><name sortKey="Josephine, Anthony" sort="Josephine, Anthony" uniqKey="Josephine A" first="Anthony" last="Josephine">Anthony Josephine</name><affiliation><wicri:noCountry code="subField">+91‐44‐2454‐0709</wicri:noCountry></affiliation></author><author><name sortKey="Amudha, Ganapathy" sort="Amudha, Ganapathy" uniqKey="Amudha G" first="Ganapathy" last="Amudha">Ganapathy Amudha</name><affiliation><wicri:noCountry code="subField">+91‐44‐2454‐0709</wicri:noCountry></affiliation></author><author><name sortKey="Veena, Coothan Kandaswamy" sort="Veena, Coothan Kandaswamy" uniqKey="Veena C" first="Coothan Kandaswamy" last="Veena">Coothan Kandaswamy Veena</name><affiliation><wicri:noCountry code="subField">+91‐44‐2454‐0709</wicri:noCountry></affiliation></author><author><name sortKey="Preetha, Sreenivasan P" sort="Preetha, Sreenivasan P" uniqKey="Preetha S" first="Sreenivasan P." last="Preetha">Sreenivasan P. Preetha</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Division of Biochemistry, University of Madras, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Rajeswari, Arjunan" sort="Rajeswari, Arjunan" uniqKey="Rajeswari A" first="Arjunan" last="Rajeswari">Arjunan Rajeswari</name><affiliation><wicri:noCountry code="subField">+91‐44‐2454‐0709</wicri:noCountry></affiliation></author><author><name sortKey="Varalakshmi, Palaninathan" sort="Varalakshmi, Palaninathan" uniqKey="Varalakshmi P" first="Palaninathan" last="Varalakshmi">Palaninathan Varalakshmi</name><affiliation><wicri:noCountry code="no comma">E-mail: drvlakshmi@yahoo.com</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Nutrition & Food Research</title><title level="j" type="abbrev">Mol. Nutr. Food Res.</title><idno type="ISSN">1613-4125</idno><idno type="eISSN">1613-4133</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2007-11">2007-11</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1413">1413</biblScope><biblScope unit="page" to="1422">1422</biblScope></imprint><idno type="ISSN">1613-4125</idno></series><idno type="istex">878595168592A567E3CAD88E8FC7A3C93BE2C88F</idno><idno type="DOI">10.1002/mnfr.200700127</idno><idno type="ArticleID">MNFR200700127</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1613-4125</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants</term><term>Cyclosporine A</term><term>Mitochondrial enzymes</term><term>Mitochondrial swelling</term><term>Sulphated polysaccharides</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)‐induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA‐induced (25 mg/kg body weight, orally) mitochondrial damage. CsA‐induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA‐induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA‐provoked nephrotoxicity.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Amudha, Ganapathy" sort="Amudha, Ganapathy" uniqKey="Amudha G" first="Ganapathy" last="Amudha">Ganapathy Amudha</name><name sortKey="Josephine, Anthony" sort="Josephine, Anthony" uniqKey="Josephine A" first="Anthony" last="Josephine">Anthony Josephine</name><name sortKey="Rajeswari, Arjunan" sort="Rajeswari, Arjunan" uniqKey="Rajeswari A" first="Arjunan" last="Rajeswari">Arjunan Rajeswari</name><name sortKey="Varalakshmi, Palaninathan" sort="Varalakshmi, Palaninathan" uniqKey="Varalakshmi P" first="Palaninathan" last="Varalakshmi">Palaninathan Varalakshmi</name><name sortKey="Veena, Coothan Kandaswamy" sort="Veena, Coothan Kandaswamy" uniqKey="Veena C" first="Coothan Kandaswamy" last="Veena">Coothan Kandaswamy Veena</name></noCountry><country name="Inde"><noRegion><name sortKey="Preetha, Sreenivasan P" sort="Preetha, Sreenivasan P" uniqKey="Preetha S" first="Sreenivasan P." last="Preetha">Sreenivasan P. Preetha</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000354 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000354 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= DanceTherParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:878595168592A567E3CAD88E8FC7A3C93BE2C88F
|texte= Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney
}}
| This area was generated with Dilib version V0.6.35. |  |